Ca2+ channels as novel therapeutic targets in heart failure
نویسندگان
چکیده
منابع مشابه
Therapeutic Targets in Heart Failure
From the *Heart Pittsburgh Schoo Cardiomyopathy C California; zCente School of Medici University, Atlanta Siemens; has receiv purposes; and has r The Pittsburgh F GlaxoSmithKline, Relypsa, Scios, St. as the Eliot Cord Ahmanson Found ew therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long-term pat...
متن کاملPotassium channels as targets for therapeutic intervention.
The potassium channel superfamily presents a rich source of targets for therapeutic intervention. Indeed, the development of specific potassium channel modulators could lead to the effective treatment of various diseases for which current therapies are clearly suboptimal. Numerous factors play a role in determining whether the successful clinical development of such drugs can ever be achieved. ...
متن کاملNew therapeutic targets in cardiology: heart failure and arrhythmia: HCN channels.
H eart failure (HF) affects ≈2% to 3% of the population in many industrialized countries 1 and is a major cause of mortality. Although widely used treatments such as β-blockers and renin-angiotensin system antagonists have largely improved outcomes in the past 2 decades, prognosis remains poor. Accumulating data collected in >200 000 individuals in various epidemiological studies support that a...
متن کاملL-type Ca2+ channels gaining respect in heart failure.
L-type Ca 2 channels are essential for the initiation and regulation of excitation-contraction (EC) coupling in adult cardiac muscle.1 The rapid influx of Ca through these channels triggers release of intracellular Ca from the sarcoplasmic reticulum (SR) stores, and the resulting Ca transient activates the myofilaments and thus contraction. Given that failing ventricular myocytes exhibit impair...
متن کاملAnemia and iron deficiency--new therapeutic targets in heart failure?
Anemia ranges in prevalence from below 10% among patients with mild heart failure symptoms to over 40% for patients with advanced disease.1 Its prevalence is similar among patients who have systolic dysfunction and among patients who have heart failure with preserved systolic function.2,3 Anemia has been associated with older age, diabetes mellitus, chronic renal dysfunction, more advanced hear...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2012
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.140.255